Where CBS was once alone, it now faces a vast array of rivals who learned from the "tiffany" network's early success and have become adept at beating them at their own game.
Federal regulators now touch areas of economic activity they once left alone, such as greenhouse-gas emissions.
Once they are alone, they wait for the prisoner to rise to her feet.
Once stand-alone devices are feasible, Quake hopes to combine them into a single chip.
Once he was alone in the plane, a Cessna 172, he started the engine and took off without permission around 5 p.m.
Few players in history have recovered from this type of procedure once, let alone twice, casting significant doubt on the future of one of the best starting pitchers of this generation.
Few consumers regret that Windows has absorbed what once were stand-alone applications such as fax programs, or that Intel now makes faster processors.
If only fences are mended with the United Nations, they have been encouraged to believe, the world will once again leave us alone.
He was a stand-alone CEO once a decade ago when he left the CFO post of Microsoft to run the Global Crossing competitor 360networks.
Whether they care to admit it or not, competition ranging from TMZ to Facebook has stolen eyeballs and relevency from these once largely stand-alone players.
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But none of this necessarily means that thinking has changed enough to keep talks going once started, let alone to produce a settlement to a dispute that has brought about two wars and a 12-year insurgency involving some 35, 000 deaths.
Most of the moments once reserved for a little alone time have been infiltrated by the realtime Internet.
In effect the hand-held consumer GPS device market is crumbling as functionality that once required a stand-alone gizmo is incorporated on a widespread basis in smart phones.
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If we'd once again leave the economy alone, non-traditional forms of finance would continue to grow, traditional banks would continue to decline in relevance, and our system of finance would be much healthier.
President Ernesto Samper has tried more than once, barely noticed, let alone aided or even commended, by those who were happy to denounce the drug money that went into his election campaign in 1994.
Where once Netflix (NFLX) stood alone, the choices for consumers interested in subscription-based streaming of movies and TV shows are expanding.
This makes Sarofim, who last appeared on the Forbes 400 in 2007, a billionaire once again on his publicly traded assets alone.
"Although the council played a significant role in these issues, the duty to establish the procedures and the implied duty to follow those procedures, once established, rested with the governors alone, " the report said.
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They did find that pessimists were also likely to have other heart risk factors such as being overweight and a sedentary lifestyle, though once they corrected for those, mood alone was still a factor.
Our commanders will soon be hard pressed to preserve today's deployments of American forces in Iraq, let alone to have them take up once again the sorts of positions in the urban areas that they held to such therapeutic effect during the surge.
Once the music begins, however, I work alone, even if the room is so crowded that my neighbor's pink slipper on the barre is nudging my hand.
One morning last week, the man who once starred at Bayern Munich and Inter Milan trudged alone across an empty parking lot at the Home Depot Center near Los Angeles, lugging a backpack and a shoulder bag to lead practice for his team's second-tier players.
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The Lower East Side once boasted 14 Yiddish theatres, with five on Second Avenue alone.
Even without Panic, Ribapharm may have problems once it breaks off from ICN and tries to go it alone in the rough waters of the biotech market.
The Eurocrat architects of the euro never believed a nation once in the club would ever need to quit, let alone be in a position that was so weak it could undermine the whole currency.
The airing of such views, let alone by senior members of the religious establishment, would once have provoked conservative rage.
"I didn't come to work alone, this country is going to make strong progress once we all realise we have to work together, " he said.
Sullivan, who once excelled at partnering with Big Media brands, is now going it alone.
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It starts to seem axiomatic that once you let violence into your life, it will never leave you alone.
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