After studies in primates showed high levels of toxicity from GDNF, Amgen halted further human trials.
The MHRA has also said there is no evidence of toxicity from the unauthorised filler.
"We have not seen any evidence of toxicity to date, " says Lieberburg.
Bittman fails to understand that the degree of toxicity is critical.
FORBES: Bittman of the 'New York Times': Always Out To Lunch
The research on herbal remedies is spotty, and reports of toxicity, product impurities, and inconsistent levels of active ingredients across brands continue to worry doctors, Schwartz says.
Mr Buffett's WMD could leave behind a cloud of toxicity.
ECONOMIST: The fallout from the bankruptcy of Lehman Brothers
The cycle goes on and the levels of toxicity increases until you get to the top of the food chain with pelagic fish such as swordfish that end up on our dinner plate.
Hard to say and impossible to avoid, the chemical is part of the silicones family (think silicone oil or grease), which has been around for 50 years, and has been noted, generally, for its inertness, lack of toxicity, and resistance to microbiological growth and heat.
FORBES: Scientists Recommend Canadian Regulation Be More Reasonable; Government Listens
My awareness of the toxicity of carbon nanotubes is that the jury is out.
He has also given public warnings of the toxicity of some anti-retroviral drugs, arguing that they might be as deadly as the disease itself.
Steven Gill, the British neurosurgeon who ran that first GDNF infusion trial, believes the cause of the toxicity was the improper infusion of the drug into the monkeys' brains.
Kynamro carries a Boxed Warning on the serious risk of liver toxicity because it is associated with liver enzyme abnormalities and accumulation of fat in the liver, which could lead to progressive liver disease with chronic use.
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
"Had trials designed to test the question of cardiovascular toxicity directly been launched in 1999 and executed with urgency...perhaps a substantial number of deaths could have been prevented, " Drazen concludes.
Two months ago it halted trials of a promising arthritis drug over fears of brain toxicity.
My understanding is that the dispersant is actually not used in several Western countries because of its toxicity.
As a result, the FDA is considering changing acetaminophen warning labels to identify the risk of liver toxicity.
Wockhardt also accused Sepracor of withholding a separate rat study from 1999 that contradicted its findings of low toxicity for the zopiclone isomer.
Because of the risk of liver toxicity, JUXTAPID is available only through a restricted program called the JUXTAPID Risk Evaluation and Mitigation Strategy (REMS) Program.
FORBES: FDA Approves Lomitapide For Homozygous Familial Hypercholesterolemia
Whereas Beveridge envisaged the welfare state as an attack on five negative giants, the social investment state should have positive aims such as the reduction of environmental toxicity.
Due to recent restrictions placed on the use of the 80 mg dose because of a higher risk of muscle toxicity, there will not be a FDC using this dose.
FORBES: FDA Approves Juvisync, Combination of Sitagliptin and Simvastatin
Earlier this year another diabetes compound, this time from AstraZeneca (nyse: AZN - news - people ), also failed in late-stage trials because of signs of kidney toxicity.
Because of the indirect mechanism of its toxicity and its specificity for human cells, the contaminant had been undetectable in both the standard, sophisticated screening tests that are supposed to assure a drug's purity and quality, and in studies in animals.
It was originally dropped as a treatment for high cholesterol by Bristol-Myers Squibb because of the liver toxicity issues, but a University of Pennsylvania cardiologist, Daniel Rader, championed the drug, leading Aegerion to develop it.
FORBES: Aegerion Cholesterol Drug Approved. Will It Treat 300 Patients, Or 3,000?
But it was concerned about what it called the "potential toxicity of the gel" as an irritant.
And we know there is some toxicity with dispersants, but it is far less than the toxicity of the oil.
For non-Australians, it is important to understand the toxicity of word "elite".
The fact is, one way or the other, somebody is finally going to have to take a hit for the toxicity of the 2000s decade.
Peterson said she is also concerned about the toxicity of mercury.
Now, the pharmaceutical industry is increasingly adopting stem cells for testing the toxicity of drugs and identifying potential new therapies, say those in the field.
In 1972, on the basis of data on toxicity to fish and migrating birds (but not to humans), the U.S. Environmental Protection Agency banned virtually all uses of DDT.
应用推荐