The top seven seeds receive a bye into the second round and the world No. 5 Juan Martin Del Potro made hard work of his place in the third round after a battle with Ukrainian Alexandr Dolgopolov.
The Orange lost three of their last four during the regular season, but earned a double-bye in the Big East tournament with a clutch 68-57 win over then-No. 13 Louisville in the season finale at the Carrier Dome.
The world No. 7, last year's runner-up to Amelie Mauresmo, has a first-round bye and will begin her title bid against Iveta Benesova of the Czech Republic or fellow Russian Anastasia Pavlyuchenkova, who meet on Tuesday.