So far, though, there have been no big problems.

ECONOMIST: Credit derivatives

Animal tests show that the compound does indeed hit the autoreceptors, and early human trials found no big safety problems.

FORBES: Magazine Article

PolyMedix Chief Executive Nicholas Landekic is optimistic--there have been no showstopper safety problems so far--but only big human trials can tell for sure.

FORBES: Magazine Article

But no state in the U.S. faces problems as big as California's.

FORBES: Magazine Article

It's not too big, not too gas guzzling, and I have no problems with it so far.

NPR: How Do Ford's Woes Play at the Auto Show?

For a couple of years I had no problems but one night, about three years ago, during a particularly big gig, I began to feel quite ill.

CNN: 'I'd be an invalid without this device'