Nicotine exposure during early pregnancy is suspected of causing problems in developing fetuses, not the least of which was thought to be that it increased the risk of a child becoming a chronic smoker.

ECONOMIST: The fetus is father of the man

The authors suggest that slow clearance prolongs the exposure of the brain to nicotine and is likely to make it more intense.

BBC: NEWS | Health | Faulty genes feed nicotine habit

More importantly, the exposure and publicity given tobacco industry documents spelling out market targeting tactics and an awareness of nicotine's addictive nature will undercut tobacco's arguments in future suits.

CNN: The Tobacco Deal: Smoke And Mirrors?