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This includes a messenger protein called NF-Kappa B, which appears to be blocked by the hormone progesterone.
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TLRs are known to activate NF-Kappa B which relays on their instructions to lead to a cascade of events.
BBC: NEWS | Health | Immunity clue to premature births
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It may be that blocking NF-Kappa B is a better way to tackle the problem than blocking the TLRs.
BBC: NEWS | Health | Immunity clue to premature births
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He says basic scientists are free to inspect the pathway, but that Ariad expects a "reasonable royalty" for commercially available drugs that impact NF-kappa-B.
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Upon ligand engagement, these receptors in turn engage MyD88 which signals through IRAK4 to turn on a variety of pathways, including NF-kB and the secretion of pro-inflammatory cytokines.
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Through further experiments in human cells and animal studies the researchers found that a protein called NF-kB lured zinc into the immune cells that responded fastest to fight infection.
BBC: Zinc 'keeps immune system in check'
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Once inside, the zinc then put the brakes on further activity in the NF-kB pathway, slowing down the immune response and limiting the amount of inflammation, the study, in Cell Reports, indicated.
BBC: Zinc 'keeps immune system in check'
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Prof John Beattie, head of the micronutrients group at the University of Aberdeen, said NF-kB cropped up in many processes in the body, including atherosclerosis, which leads to blocked arteries seen in heart disease and has been linked to zinc deficiency.
BBC: Zinc 'keeps immune system in check'
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Mrs Crawford's son-in-law Steve Hammond said NF should have been diagnosed earlier.
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Evelyn Crawford, 69, of Welland, died on Saturday after contracting the rare flesh-attacking bacterial infection necrotising fasciitis (NF).
BBC: Woman's fatal flesh-eating bug mistaken for allergy