Fifty-seven new compounds are in human testing, triple the size of its disclosed pipeline in 2002.
But over the last four months, drug companies have unveiled a pharmacopoeia of promising new compounds.
Some of the new compounds lasted over three times as long, up to 73 days.
The new compounds are not yet ready for testing on people, according to Dr Blackwell.
It's planning on rolling out 11 new compounds over the next five years.
These new compounds are mostly synthetic rubber, and compounds are evolving fast.
Most research chemists are like generals playing molecular trench warfare, firing out thousands of new compounds in a grueling advance toward the elusive billion-dollar molecule.
Roche now has 27 drugs in late-stage testing, up from 5 in 2000, including promising new compounds for asthma, arthritis, anemia, incontinence, diabetes and depression.
The chemistry was tedious and new compounds hard to come by.
AstraZeneca and Naurex say their new compounds deliver the rapid benefits of ketamine without the disturbing side effects because they act differently on the NMDA receptor.
To find out if the new compounds can alter the course of infection in an animal, Dr Blackwell's group infected some cabbage white butterfly caterpillars with P. aeruginosa.
Ultimately, cardiologists hope to create a powerful new triple-threat cocktail combining today's statin drugs for lowering bad cholesterol (like Lipitor) with new compounds to boost good cholesterol and other drugs that would directly reduce vessel-wall inflammation.
The trick to getting this center going will be to get a few good startups hatched fast, so that venture capitalists and Big Pharma will start to see it as a go-to place for new compounds.
"By linking up computer technology with the science of olfaction, we can speed up the creation of new compounds, and it can take us into areas we've never dreamed of, " says Rahman Ansari, vice president of technical affairs at Quest International, a unit of British chemical giant ICI that developed Este Lauder's blockbuster Tommy Girl.
In collaboration with Brian Bachmann at Vanderbilt University, we screened some of these samples for new antimicrobial compounds.
The consortium is working with Chiron, a biotech firm, on an early-stage trial of a new anti-cancer drug, with several new centres and compounds expected to enter the network over the coming months.
Like Watson, Horton believed the fastest and cheapest way to aid poor countries was to turn existing laboratory compounds into new drugs.
Like Watson, Horton believed the fastest and cheapest way to aid poor countries was to turn existing lab compounds into new drugs.
Dr Kanatzidis's group is developing new ways of making these compounds crystallise correctly.
So far Dr Ausubel and his colleagues have managed to test around 37, 000 compounds using their new method, and they have found 28 that have antibiotic properties.
Ultimately such compounds could lead to promising new painkillers, but to reach that stage GSK's labs first have to test hundreds of thousands of different compounds with the vanilloid receptor, hunting for the ones that bind.
Ford's new solution captures the volatile organic compounds from paint waste and concentrates them into a rich mixture of hydrocarbons.
This method of testing new drug ideas against many thousand compounds - High Throughput Screening (HTS) - is likened to searching for a very small needle in a very large haystack.
Third, the FDA and other regulatory bodies are going to use all means possible to get drug companies to run outcome studies like HPS2-THRIVE to learn about compounds both old and new.
Diversa is also chasing drug compounds, looking for its own new antibiotics.
Some had hoped that Merck would use the proceeds from a Medco spinoff to purchase new drugs, either buying entire companies or specific compounds.
The new clinical-trial registries apparently will not apply to compounds that don't make it to market.
Gilead is frustrated because Stribild, a once-a-day pill that was approved last summer, contains four Gilead compounds, but only two of which have new active moieties.
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Including Xigris, Lilly plans five new drug launches in little more than a year, with another eight drug compounds on the way.
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