He reacted quickly after home keeper Boaz Myhill had palmed out Denilson's swerving shot.
Hull looked nervous and Jobi McAnuff's deflected shot had keeper Boaz Myhill scrambling across his goal.
The Bolton striker first forced a corner with a 25-yard shot which Boaz Myhill parried.
Myhill immediately released Richard Garcia down the right and he curled a long ball into the Bolton area.
William Gallas clattered the crossbar in the 83rd minute before a brilliant late Boaz Myhill save denied Fabregas.
The changes nearly had their desired effect on 80 minutes, but Van Persie's strike just evaded Myhill's right-hand post.
And he was almost rewarded within seconds, but Myhill saved well from Priskin's rising shot at his near post.
He lofted the ball over the onrushing Myhill, but it drifted agonisingly wide.
Half-time substitute Roger Guerreiro brilliantly chipped Wales goalkeeper Boaz Myhill 10 minutes from time to secure victory for the Poles.
It got even worse in injury time as Riera's shot struck Babel and looped over Myhill to make it six.
It got worse when Benayoun's cross was only cleared to Skrtel, whose shot was diverted past keeper Myhill by Kuyt's header.
He got away down the left side and picked out Cole, only for the in-form forward to fire straight at Myhill.
Poland threatened with a couple of Guerreiro free-kicks, the first arcing over and Myhill doing well to punch away the lofted second.
Toshack is without a host of players including Premier League quintet Craig Bellamy, James Collins, Jack Collison, Simon Davies and Boaz Myhill.
By now, City were rampant and only a series of super saves by Myhill stopped Kolarov and Silva adding to their tally.
Moments later, Gary O'Neil rattled the crossbar with Myhill beaten this time.
Wales boss Toshack made five changes at half-time, with Myhill, Ramsey, Sam Vokes, Carl Fletcher and David Cotterill all coming off the bench.
Spurs responded with spirit, and Roman Pavlyuchenko should have equalised after a mistake by Paul McShane, but could only shoot straight at Boaz Myhill.
The Latics took until the 87th minute to respond when Myhill spilled Jordi Gomez's cross-shot and Sinclair reacted quickly to nod home the rebound.
But Myhill could do nothing to prevent Tevez completing his fourth hat-trick in English football shortly before the break when Atkinson awarded another penalty.
West Brom came back strongly and Ryan Donk had a header cleared off the line before James Morrison saw his shot well saved by Myhill.
Fernando Torres had a 10-yard angled sidefoot tipped over by keeper Boaz Myhill but having survived that early scare Hull quickly set about their task.
Torres dribbled around Boaz Myhill to restore the Reds' lead and rolled in to complete his treble after latching on to a clever Yossi Benayoun pass.
With four minutes of injury time signalled, Myhill produced a brilliant save to parry Fabregas's powerful 20-yard strike to earn Hull their first ever victory against Arsenal.
Ronny Buchel easily split a static defensive line and left Hasler a clear run at Myhill, the forward firing past the keeper but wide of the posts.
Neil Warnock's side piled more misery on City by knocking three more past Myhill after former Blade Uhlenbeek was red-carded for a bad foul after 56 minutes.
Toshack also pointed out that Hennessey's place could be under increasing pressure from Hull's Boaz Myhill who is likely to playing regularly in the top flight with his newly-promoted club.
The Hammers almost equalised when Cole's shot from five yards out beat Boaz Myhill, but he saw his effort come back off the underside of the bar.
Viduka nearly doubled the lead soon after, skipping past two defenders and cutting in from the right only to drag his shot wide of Boaz Myhill's right-hand post.
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