It is supposed to be much more difficult to show a benefit in the "hard events"--heart attack, stroke and death--than in the broader swath of "extra" heart problems that AtheroGenics measured in its trial.
"There are local factors in Syria that are going to make it much more difficult to have an effect -- the middle classes in Syria have yet to really throw their lot in with the opposition, " he said.
Building the passionate sales force and a similar culture to Groupon would be much more difficult to achieve.
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Wayne's out of contract, he's one we'd liked to keep but it might be much more difficult to do that now.
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Ms McLennon also said once a person became homeless they had to face stigma and found it much more difficult to get a job.
Rather than simply deleting files - which could then be undeleted - the worm resets the file size to zero bytes, making them much more difficult to recover.
Unlike power plants, which are few in number and so easier to regulate, cars are ubiquitous and much more difficult to control.
Though it is relatively easy to mock up a website, it is much more difficult to mask exactly where that website sits in cyberspace.
"As we arrived, although people were trying to clear the roads, the snow was continuing to fall and it was just making it much more difficult to get to people and to get them back out of the area, " he said.
"Of course, if this were to (spread to the community), it would make it much more difficult to control, " he said.
Prof Benton added that evolutionary change added an additional pressure to population management schemes, namely that it was much more difficult to reverse than ecological change.
But due to its significantly larger size and larger debts, it would be much more difficult to rescue.
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If his enemies and interlocutors did not pretend to half-believe the half-fiction, it would have been much more difficult to negotiate the Good Friday Agreement.
If the figure ends up being closer to 50%, which some analysts believe likely, long-term climate targets will be much more difficult to achieve.
So it has been much more difficult to play some of the standard charts.
We live in an age when it is much more difficult to keep secrets.
But she said it was much more difficult to pin down any long-term effect.
And it's much more difficult to gauge popular sentiment in Iran outside the capital.
But it will be much more difficult to catch up with the US - Silicon Valley.
"With term limits you've made it much more difficult to reasonably control the council, " Mr. Vallone said.
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This is a conundrum, as the sense of meaning is much more difficult to acquire than possessions.
This opens up a whole new group of schools that were formerly much more difficult to get into.
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This would, as a practical matter, make it much more difficult to constrain the transfers of such technologies.
As a tablet, it is much more difficult to use than its competitors due to its weight and thickness.
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And private equity would find it much more difficult to function without the rule that allows interest to be tax-deductible.
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Unlike hospitals, which operate under the rubric of large regulatory agencies, physicians have been much more difficult to regulate and monitor.
When a market has been rising for almost four years it is much more difficult to find stocks with long-term bases.
Secrets have become much more difficult to keep in the age of social media, even if bullets remain just as deadly.
The duck-and-cover would be much more difficult to pull off in first-person.
The basic problem is that productivity in services is very much more difficult to increase than it is in manufacturing or agriculture.
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