Correlation coefficients represent how closely two variables are related -- in this case MRI of the brain and OCT scans.

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But then MRI scans spotted a small, fast-growing lesion inside his brain.

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To process the MRI data, a computer overlaid on Pickens' brain a virtual three-dimensional grid of 50, 000 cubes called voxels (a word hinting at volume and pixels).

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Dr. Wolinsky said the next study he expects to pursue will use functional MRI imaging to measure changes in the brain in people participating in cognitive-training exercises, he said.

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Throughout the 75-minute test participants were shown responses given by four other subjects, while the MRI machine snapped 1, 000 brain images.

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