As previously reported, the Bextra label also includes a "black box" warning--the most serious kind--for a dangerous skin condition called Stevens-Johnson Syndrome.
In an editorial earlier this year in The Lancet, a medical journal, Topol called for the FDA to put a black box label--its most serious warning--on Vioxx.
The label for Eloxatin will contain a "black box"--the FDA's most serious--warning of those side effects.
But Wednesday's security breach - the most serious in living memory - is certain to spark calls for this ancient arrangement to be brought to an end, in favour of something more modern.
"The accusation that the NBC broadcasts may provoke copycat attacks - the most serious charge against the network - appears to rest on a notion of severe mental illness as contagious, " wrote Bronwen Maddox of the Times.
If you are elected president, what will you take to that office thinking is the single-most serious threat to the national security of the United States?
Over the last 12-month period the Secamb answered 75.2% of the most serious time-critical calls within target.
The crisis of confidence in the ability of eurozone countries with huge borrowings to repay all they owe has already deteriorated into a banking crisis - whose most serious manifestation to date has been talks to rescue the big Franco-Belgian bank Dexia.
"This move is in accord with the Pope's oft-repeated image of the Church as a 'field hospital' that goes out to meet people where they are most in need, and then to treat their most serious wounds first -- rather than stay at home and wait for people to come to them, " said the Rev.
He said ambulances were missing their targets "in responding to the most serious life-threatening callouts".
BBC: London ambulance handover waiting times to A&E 'rising'
Bernstein says that in the best-case scenario, Tysabri would get a black box warning--the most serious kind.
Marshall was convicted in October of the most serious charges -- first-degree grand larceny and scheming to defraud.
Most serious regulation-watchers would say that anyone who buys that number must also believe in the largess of the Tooth Fairy.
The most serious long-term risk, of course, comes from higher prices.
And so, like a sleepwalker who strides into danger and then wakes up with a gulp, the administration has stumbled into the most serious foreign-policy crisis of its six years.
The most serious stand-off today is not the US and Russia but the prospect of a nuclear exchange between India and Pakistan in which "tens of millions would die", Rogers suggests.
Drake pleaded guilty to a misdemeanor charge of exceeding his authorized use of an agency computer after authorities dropped the most serious charges -- including some under the Espionage Act -- against him.
The International Atomic Energy Agency has classified the Tokaimura accident, which was the worst in Japanese history, as level four on its seven-point scale, making it the world's most serious since the level-seven disaster at Chernobyl in 1986.
It uses high-tech medicine sparingly to treat the most serious conditions while employing nutrition, exercise, stress-reduction and other simple, low-cost (or free) interventions to foster long-term health and resilience.
Texas has also recorded at least 495 cases of the most serious, neuro-invasive form of the illness.
It soon escalated into Indonesia's worst outburst of communal violence - and the most serious in Southeast Asia for decades.
Opening the debate, Justice Minister Crispin Blunt said EU criminal law should centre on combating the most serious of cross-border crimes.
Do you think this is the most serious challenge he faced - he's been there 23 years as commissioner?
Environment Secretary Caroline Spelman is expected to announce next month that the charges will be outlawed in all but the most serious cases of fly-tipping.
Most serious collectors prefer more-refined "city carpets, " such as Iranian Ardabil rugs, made of 100% New Zealand worsted wool and boasting 150 to 200 knots per square inch.
Although the CDF did not have formal responsibility for child abuse cases until 2001, the Murphy case should have been referred to the Congregation because it involved solicitation in the confessional - one of the most serious offences under church law.
On Tuesday, health officials said two young children, aged about 12 months, had contracted the most serious strain of the bacteria - 0157.
It comes just days before Mugabe could face the most serious challenges to his decades-long rule in the March 29 presidential and parliamentary elections.
The fighting, which eased at nightfall, was by far the most serious violation of a cease-fire brokered by NATO and the European Union that took effect July 5.
The judge told Summers he took into account that he was not responsible for what may have been the most serious aspect of the assault - stamping on Mr Ferry's head.
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