High-throughput screening uses robots to test the actions of thousands of compounds against a molecular disease target (itself identified by genomics).
Scientists probing the molecular origins of heart disease are discovering surprising parallels between these two kinds of disorders, paving the way for new treatments.
The MRC-NIHR Phenome Centre will look for new molecular 'biomarkers' for disease by analysing samples from patients and volunteers.
Into this gloom comes Novartis' Glivec, the first leukemia drug designed to attack the molecular machinery that drives the disease.
SU-11248 is one of a new spate of cancer pills that work by targeting several of the molecular defects that cause the disease at one time.
"My vision is that we will have drugs targeting key elements of molecular pathways" that go awry in disease, Fishman says.
By 2000, scientists had identified nearly 40 other genes involved in the disease, as well as various other molecular changes that cause muscles to waste away.
"The disease is common, but the fatalities are the puzzle we're trying to figure out, " says Dr. Jim Alexander, a molecular virologist with the Atlanta-based Centers for Disease Control and Prevention.
When Schleifer, a 50-year-old neurologist, cofounded Regeneron with George Yancopoulos , a molecular immunologist, the main target was Lou Gehrig's disease.
The University of Colorado researchers are studying molecular mechanisms of normal acclimatization in healthy people to gain new treatment ideas for people with chronic obstructive pulmonary disease, or COPD, a common lung disease.
WSJ: Mayo Clinic Researchers on Everest Study High Altitude's Effects on the Body
"Obesity is a disease that is crippling the healthcare system, " says Stephen Friend , Merck's vice president of molecular profiling.
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