Tries from Lee Byrne (2), Nikki Walker, Shane Williams (2), Sonny Parker and Mike Phillips secured victory.
Jamie Heaslip, Mike Phillips, Alun-Wyn Jones, Phil Vickery and Lee Mears are all promoted from the bench.
The Lions, though, had already built a clear lead, inspired by scrum-half Mike Phillips, who scored two tries.
Wales will be without first-choice scrum-half Mike Phillips (foot) for their tricky Six Nations opening trip to England.
Warriors have been linked with Welsh stars Ceri Sweeney and Mike Phillips but Ruddock would not be drawn.
They also confirmed their two other long-term injury victims Mike Phillips and Ben Lewis will return on time.
Rhys Webb and Rhodri Wells will contest the scrum-half jersey in the absence of Mike Phillips and Jamie Nutbrown.
With Mike Phillips injured and Justin Marshall gone, the Ospreys have Rhodri Wells and teenager Rhys Webb as nines.
Rees has moved above Peel to become Gatland's back-up scrum-half behind British and Irish Lions star Mike Phillips for Wales.
Osprey Nutbrown's fellow number nine Mike Phillips returned from nine months injury absence in last Friday's defeat at the Dragons.
Marshall's Ospreys future was thrown into doubt last year when the region recruited Wales scrum-half Mike Phillips in a big-money deal.
Gatland dropped a hint that Dwayne Peel is under major pressure from Mike Phillips to keep hold of the scrum-half jersey.
Blues team-mate Gareth Cooper, Dwayne Peel and Mike Phillips, who has a dead leg, are the other nines in the squad.
Mike Phillips, chief technology officer for Vlingo, which Nuance agreed to acquire last year, said Article One had an "innovative" approach.
With Gareth Cooper part of Gloucester's Guinness Premiership play-off push and Mike Phillips out, London Irish's Warren Fury, 22, comes in.
Centre Jamie Robinson, scrum-half Mike Phillips and prop Adam Jones all went as probables and did nothing to harm their chances.
Scrum-half Mike Phillips gets his first start, with Jenkins also naming an entirely new front row from the team that faced Australia.
If Peel and Cooper are absent while Osprey Mike Phillips' recovery from knee surgery continues, Scarlets rookie Martin Roberts would play against Australia.
The Ospreys said the move had come as no surprise as Marshall faced intense competition from Mike Phillips for the region's scrum-half position.
Ospreys half-back pair Mike Phillips and James Hook had had a decent enough game - Hook claiming a fine try and kicking his penalties.
Williams tore a hamstring in Saturday's 33-12 loss to Australia and joins fellow stars Mike Phillips, Lee Byrne and Adam Jones on the sidelines.
Scrum-half Mike Phillips is given the chance to build match fitness after being among the six unused replacements when Wales took on the French.
Long-term casualties Matthew Rees and Mike Phillips' recoveries are on target, Rees set to be ready for the opener against England on 6 February.
Mike Phillips, Dwayne Peel, Mike Blair, Tomas O'Leary, Peter Stringer, Harry Ellis and Danny Care all have a good case for inclusion at scrum-half.
British and Irish Lions full-back Byrne is recalled for his 40th Wales cap as Hook is moved forward to partner Mike Phillips at half-back.
"We had a very hard decision to make, but were impressed by the performances of Mike Phillips and Gareth Cooper, " said Wales coach Warren Gatland.
At outside half, Gatland will have Owen Farrell and Jonathan Sexton, while his scrum half options will be Conor Murray, Mike Phillips, and Ben Youngs.
Williams says he has the utmost sympathy for Peel, who is replaced at number nine by Mike Phillips, but is sure he will bounce back.
The four were questioned, along with team-mates Lee Byrne and Mike Phillips, by team managers about what they were doing in Cardiff city centre on Sunday.
Mike Phillips is the favourite to start at scrum-half but Blair's ability to make darting breaks around the side of the breakdown will scare the Boks.
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