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Stead showed incredible bravery to meet Jagielka's cross ahead of Wigan keeper Mike Pollitt and head home.
BBC: Sheff Utd 1-2 Wigan
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The Blades had a late chance to equalise against 10-man Wigan but Danny Webber hit the post when one-on-one with keeper Mike Pollitt.
BBC: Warnock hits out after relegation
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However, they were only brief forays into the opposition half and former Latic Valencia soon added United's fifth of the night, running on to Rooney's slide-rule pass to chip over substitute keeper Mike Pollitt and into the far corner.
BBC: Manchester United 5-0 Wigan
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Boyce and Scharner played key roles in last season's successful battle against relegation, while Mike Pollitt provided back-up to keeper Chris Kirkland.
BBC: Wigan trio offered new contracts
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Tempers had flared towards the end of the first half with the concession of a few free-kicks and Kilmarnock midfielder James Fowler and Motherwell keeper Randolph were both booked by referee Mike Tumilty for clashing in the tunnel en route to the dressing rooms.
BBC: Sport - Football - Kilmarnock 0-1 Motherwell
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Notts keeper Stuart Nelson then saved Bradley Wright-Phillips' penalty after Joe Ayinsah was fouled by Mike Edwards.
BBC: Sport - Football - Notts County 1-0 Charlton