Robert Chalmers, 59, denies murdering Samantha Wright "by means unknown" and hiding her body in a garden bin.

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Mr Kane is accused of hitting his gran on the head with a blunt implement, applying pressure to her neck by means unknown and murdering her.

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Prosecution lawyers claim that Mr Conning seized hold of her, locked the front door of the property and prevented her from escaping before striking her by means unknown.

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The face-lift analogy works here because VWO is by no means a young, unknown prospect.

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That means the only financial unknown is how long you will live, rather than how much your future care will cost.

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The flow of people in from the countryside means that they now bustle with an unknown number of citizens.

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But getting to the big improvement means you have to go through the pain of the unknown.

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That means 19 out of 20 people who have acute pancreatitis for unknown reasons will never have it again.

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When water, person-to-person and other means of transmission are included, the full tally of acute gastrointestinal illnesses from known and unknown pathogens leaps to 210m cases a year.

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