Defeat was a blow to Henman's hopes of qualifying for the end-of-season Masters Cup.
His performances earned him a place at the prestigious end-of-season Masters Cup for the first time in his career.
The top eight players in the ATP Champions Race earn places at the Masters Cup in Shanghai.
Del Potro, 20, is currently seventh in the race to make the eight-man field for next month's Masters Cup.
Roger Federer, speaking in Shanghai ahead of the season-ending Masters Cup, said officials should come down "very hard" on gambling.
The Briton still has a slim chance of qualifying for the Masters Cup but would realistically need to win here.
The 22-year-old, who pulled out of the end-of-year Masters Cup in Shanghai, has been struggling with tendonitis in his right knee.
But a strong finish to the year, including a tournament win in Vienna, ensured his place in the end-of-season Masters Cup.
Tenth seed Carlos Moya booked his place in the end-of-season Masters Cup when he beat Frenchman Sebastien Grosjean 3-6 7-6 (12-10) 6-1.
The eight players in the Masters Cup field are: Nadal, Gasquet, Federer, Fernando Gonzalez, Novak Djokovic, Nikolay Davydenko, Andy Roddick and David Ferrer.
"To achieve something like that at his age is amazing, " Murray told BBC Sport, before flying out to Shanghai for the season-ending Masters Cup.
The Dutchman beat top seed Srichaphan 7-5 6-1, dealing a serious blow to the Thai's hopes of making the Masters Cup in Houston next month.
American James Blake lost 4-6 7-6 6-4 to Croatia's Ivo Karlovic, a defeat that gives Andy Murray renewed hope of reaching the season-ending Masters Cup.
It was Federer's first loss on indoor hard courts since the Argentine rallied to beat him at the Masters Cup in Shanghai nearly two years ago.
Federer is due to play in the Madrid Masters later this month, followed by the Swiss Indoors in Basel, the Paris Masters and Tennis Masters Cup.
Nalbandian has made quiet progress through the draw to his first Masters Series final, and victory will bring him into contention for a Masters Cup place.
Second seed Gonzalez, seventh in the Masters Cup race, overcame Croatian qualifier Roko Karanusic 6-4 7-6 to set up a meeting with unseeded Finn Jarkko Nieminen.
The Australian Open finalist could be out of action for up to three weeks - hitting his hopes of winning a place in the end-of-season Masters Cup.
Ferrero was earlier knocked out of the Paris event by Jiri Novak but he and Roddick will go head-to-head for the year-end top spot at the Masters Cup.
The big-serving Russian, who is the world number seven, is aiming to secure his place in the season-ending Masters Cup for the top eight players in the rankings.
The Scot must win the tournament to keep alive his slim hopes of qualifying for the Masters Cup and will meet fifth seed Dmitry Tursunov in the last eight.
Haas' defeat means he can no longer qualify for the Masters Cup and it also caps a miserable year for the German, who has not won a title all season.
Five of the eight qualifying berths for the Masters Cup are already accounted for with Federer, Rafael Nadal, Novak Djokovic, Nikolay Davydenko and Andy Roddick through to the prestigious finale.
Rarely can Hewitt have looked so downbeat on court and Safin served out for the biggest win of his year, and a huge boost ahead of the Masters Cup later this month.
And despite missing three months of this year through injury, Murray was still just one victory from securing a place in the Masters Cup - currently under way in Shanghai - for the world's best eight players.
Shanghai has made way for London and the Tennis Masters Cup has been rebranded the ATP World Tour Finals, but the principle remains the same - the best eight players in the world battling to end the year as the world champion.
He is a two-time US Open Champion and has won all four Grand Slam singles titles, and has victories in Davis Cup, Masters Series and an Olympic gold medal thanks to his precision and exceptional timing.
Donald, who is now guaranteed to occupy the No. 1 position heading into the Masters next month, backed his European Ryder Cup teammate to maintain his challenge at the top of the sport.
However, Murray is expected to participate in the Rogers Cup in Toronto, the sixth ATP Masters Series event this season, starting 21 July.
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