Compared with other smart cards in China, Hainan's marker has a number of advantages.

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If the number hits a different marker, it could generate a different trading strategy.

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"All these studies tell us is it is much more complicated than just trying to fix that number because that is a surrogate marker, or a predictor for the disease, not the disease itself, " says Robert Centor, a professor of internal medicine at the University of Alabama, Birmingham.

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Meadlands has pupils who between them speak 22 different languages and the number of pupils qualifying for free school meals - a standard marker of deprivation - is higher than the national average, as well as the local average.

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She set the marker for success in 2002 when she became the first of the sisters to become world number one.

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Big effects can translate into big tests: If a specific number variant is linked to sufficiently high possibility of autism, that variant could serve as an identifiable marker for the condition.

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