This had a marked effect on the size of the treated tumour, and also seemed to encourage tumour regression in other parts of the body.

BBC: NEWS | Health | Immune boost 'widens cancer fight'

"All of the updated data that we have collated supports the conclusion that claims management companies have had a marked effect on the number of small injury, whiplash-like claims, " said David Brown, chairman of the actuaries' professional body.

BBC: Traffic

The first open skies agreement, which came into effect in 2008, marked a significant step in the liberalisation of the transatlantic airline industry.

BBC: Second open skies deal signed

And even in America, where the effect will be less marked, the retirement of the baby-boomers (which has just started) means that companies will lose large numbers of experienced workers over a short period.

ECONOMIST: The battle for brainpower

One optimistic note for the near term, though: Tax selling, which tends to depress stock prices, will end in December and thus lay the groundwork for a January effect (when investors gobble up the marked-down stocks, leading to a mini-rally).

FORBES: Buy Some Insurance

If it passes successfully through the Assembly, the bill will bring changes introduced at Westminster which have marked the biggest overhaul of the benefits system since the 1940s, into effect in Northern Ireland.

BBC: Social Development Committee part one

This February 22 marked the one year anniversary of the Credit Card Accountability Act being put into effect.

FORBES: One Year after the Credit Card Accountability Act

That incident marked Aberdeen's seventh sending-off already this season, but it had the effect of jolting the game back to life and Langfield was tested by both Craig Conway and Jon Daly.

BBC: Aberdeen's Davide Grassi and Charlie Mulgrew

Recently, it has been marked by structural tensions, as the writers struggle to contain an overgrowth of subplots an unfortunate side effect of their remarkable world-building skills.

NEWYORKER: Net Gain