Palace might have won the game in regulation but for some second-half heroics by goalkeeper Manuel Almunia.
England coach Fabio Capello was thought to be keen on picking Spaniards Manuel Almunia and Mikel Arteta.
Meanwhile, Arsenal goalkeeper Manuel Almunia believes this season could see the tightest Premier League title race in years.
More poor defending from Gilberto gifted an opening for Fabiano, but the Brazilian's effort was straight at Manuel Almunia.
He raced forward and found Drogba, who swept past Gael Clichy with embarrassing ease before powering a shot beyond Manuel Almunia.
Manuel Almunia raced out of goal to halt Jones, but the rebound fell kindly for Wallace, who finished in composed fashion.
Spurs opened the scoring in the 13th minute with former Gunner David Bentley beating keeper Manuel Almunia with a superb 40-yard volley.
However, the rest of the Arsenal defense were slow to react and Pedro found Messi, who smashed his shot past Manuel Almunia.
Nasri, 23, limped off as he chased a long kick up-field from keeper Manuel Almunia in a game the Gunners won 2-1.
Vermaelen saw red just before the break for bringing down Guillermo Franco, but Alessandro Diamanti saw his spot-kick well saved by Manuel Almunia.
Robin van Persie nodded against the bar before a horrendous mix-up between Manuel Almunia and Sebastien Squillaci gave Peter Odemwingie a simple finish.
First the Paraguayan blazed over from 12 yards with Arsenal keeper Manuel Almunia stranded, and then he headed over a brilliant Brett Emerton cross.
They even had the strength of character to cope with losing goalkeeper Manuel Almunia to injury in the closing stages to keep United at bay.
Fabianski had firmly established himself in Arsenal's starting XI this season, taking over the number one role when Manuel Almunia suffered an ankle in September.
Wenger refused, however, to single out Manuel Almunia for criticism, despite a poor performance from the Arsenal goalkeeper that is sure to come under scrutiny.
West Brom went close through Do-Heon Kim and Ishmael Miller, who both forced Manuel Almunia into action, while Johan Djourou made a clearance off the line.
However, Gunners goalkeeper Manuel Almunia saved Alessandro Diamanti's resultant penalty to preserve the lead given to the home side by midfielder Denilson in the fifth minute.
The Scotland forward dusted himself off before delicately placing his 20-yard free-kick into Manuel Almunia's top-left corner, despite the Spaniard getting a hand to the ball.
Steven Pienaar raced clear and dinked the ball over Manuel Almunia to make it 2-1 but Rosicky's shot was deflected in to salvage a draw for Arsenal.
Luyindula dragged a shot wide for PSG in the first half, while Pauleta sent a poor shot wide and was twice denied by the impressive Manuel Almunia.
He took a Huddlestone header and teed himself up for a stunning volley from 40 yards that Arsenal keeper Manuel Almunia touched but could not keep out.
Cristiano Ronaldo had a header saved and hit the bar with a second-half screamer, while Carlos Tevez saw a close-range effort brilliantly stopped by Gunners keeper Manuel Almunia.
Alan Smith slid in on Manuel Almunia while Joey Barton cleaned out Gilberto as the Magpies harried and harassed their opponents to try to nullify Arsenal's smooth passing play.
Spaniard Manuel Almunia has kept Lehmann out of the starting line-up this season, prompting speculation that the latter could move in order to safeguard his place in the German team for Euro 2008.
After turning Gael Clichy inside out, Varela crossed a relatively harmless ball in from the right, only for the Polish keeper, in for the injured Manuel Almunia, to spill the ball into the net.
Porto applied brief pressure after the interval, with Manuel Almunia saving from Falcao, but Arsenal completed the formalities and cruised into the quarter-finals with two superb goals inside three minutes just after the hour.
If he does, 41-year-old Jens Lehmann will drop to the substitutes bench - unless Manuel Almunia, who deputised for Szczesny until hurting a knee in the warm-up for the Blackpool game, is passed fit.
Without their captain the Gunners lack their usual midfield zest and Burnley equalized six minutes after the half-time interval when David Nugent latched on to Leon Cort's header and directed the ball over goalkeeper Manuel Almunia.
But Hull regained parity with a sensational strike from Geovanni, who skipped past a challenge on the left before drifting infield and smashing a right-foot shot that thundered into the top left-hand corner of Manuel Almunia's net.
Bolton, who had been beaten 2-0 by the Gunners on Sunday, raced into an early lead through Gary Cahill who finished well from close range to direct his shot past Arsenal goalkeeper Manuel Almunia in the seventh minute.
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