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Preston almost levelled after the break but goalkeeper Vito Mannone tipped Iain Hume's long-range drive on to the post.
BBC: Preston 0-2 Hull City
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The visitors, with new owner Carson Yeung watching from the stands, hit back through veteran midfielder Lee Bowyer in the 38th minute after a mistake by young keeper Vito Mannone.
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Seven minutes after the break, Hume's low drive looked destined for the bottom corner, but the slightest of touches from Mannone was enough to keep it out, the ball striking the inside of a post and rolling along the goal-line.
BBC: Preston 0-2 Hull City