There's Antonello da Messina's skeptical young man with thick curling hair and a black cappuccio (1478) and Laurana's nuanced marble of the introspective bluestocking Beatrice of Aragon (c. 1474-75).
The average man in 1820 lived only a bit better than his forebears had in 1500, despite the accomplishments of Leonardo da Vinci, Sir Isaac Newton and Thomas Jefferson.