But the special circumstances of the Provenge case make this decision difficult to predict.

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All of these represent terrific entrepreneurial teams, which make this decision so difficult.

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If Mannkind stumbles again Mann may have to make the difficult decision to liquidate parts of this portfolio, something he wasn't willing to do to keep either his philanthropy or airplane company going.

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"This was a difficult decision for the club to make given Jason's commitment and dedication over many years, " said Tagg.

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