Republican National Committee Chairman Ed Gillespie told CBS that Nader's candidacy would make no difference to Bush's re-election bid.

CNN: Edwards: 'Ready for this fight'

The confirmation of Richard's remains may make no difference in the royal world, but it does mean the king will finally get a proper burial.

CNN: Back from the grave, King Richard III gets rehab

Finding treatments for Alzheimer's and other dementias is no easy task, but it's one we must tackle if we are to make a real difference to people's lives.

BBC: Million 'dementia friends' wanted for training