Such a program could easily make it hard to sell the drug at all.
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The oddities of Japan's party system make it hard to predict what this means.
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"Many of these changes make it hard to return to a healthy weight, " he says.
Awkward though this is, e-mail's rigid protocols make it hard to innovate in the in-box.
Resistance from local governments and powerful state-owned companies will make it hard to implement such measures.
This aim is laudable, but three things will make it hard to carry out.
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Higher-than-usual unemployment and erratic wage growth make it hard to find that kind of money.
Another worry is stifling bureaucracy and regulation, especially laws that make it hard to sack workers.
Modern health and safety rules, for example, make it hard to run a scrap-metal business.
Sceptics say Ethiopia's shoddy infrastructure may make it hard to produce the volumes of shoes required.
Just the political issues involved might make it hard to find inexpensive space on a launch vehicle.
This has driven down shares sharply as lower yields would make it hard to justify a premium price.
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Regulatory costs have increased as well, as negative public sentiment will make it hard to come by permits.
Stress, anxiety and negative thoughts make it hard to get a good night's sleep, resulting in fatigue and lethargy.
These results make it hard to argue against the principle that when it comes to LDL, lower is better.
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Such complications may make it hard to judge which party, at the national level, has actually won these elections.
Needless to say, such lousy investment returns make it hard to raise capital.
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But self-imposed restrictions on arms exports make it hard to work more closely.
South African labour laws make it hard to fire workers, which deters companies from hiring them in the first place.
One sign of greater labour-market flexibility is that companies are bypassing stringent job-protection laws that make it hard to fire workers.
After all, some make it hard to find their quarterly earnings data.
These "learned effects" can make it hard to convince people to change their habits, even if the alternative is easier to use.
Flawed statistics on portfolio flows make it hard to tell how much it has done so, but institutional investors polled by J.
The country's creaking railways make it hard to move the stuff, as does the absence of a mechanism to negotiate bulk rail contracts.
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The tight anti-laundering rules drawn up by Saadiyat's consultants will make it hard to attract some of the more suspect sorts of deposits.
And oh, yeah: Most food-service vendors like cash on delivery, so a slow week can make it hard to buy next week's ingredients or alcohol.
Neither of these businesses has been penalized in Google's search results, and their linking strategies make it hard to distinguish paid links from legitimate ones.
Such ploys can make it hard to identify exactly who is behind a particular online assault, says Adam Vincent of Cyber Squared, another security firm.
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This can make it hard to feel an enduring sense of belonging in the city, but locals said it is easy to find friendly people looking to connect.
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