Acquisitions are stalling because of frozen credit markets, which make it difficult to locate financing.
The composition of unrealized portfolios, however, will make it difficult to burn through the exit backlog.
Approving Provenge might make it difficult to find out whether Provenge's benefits are real.
If the drug is approved, it may make it difficult to conduct that placebo-controlled trial.
Rewards like that should make it difficult to conceal wrong-doing that involves large sums of money.
It said the government's new funding formula would make it difficult to support some rural schools.
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However, carbon-14 is only found in trace amounts, which can make it difficult to detect.
Facebook does everything it can to disrupt the game and make it difficult to interact.
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Lincoln to attract consumers, but it will also make it difficult to attract qualified dealers.
This would make it difficult to focus on California's biggest long-term problem: the budget.
Other annual adjustments to the index make it difficult to compare mortality rates from year to year.
Many treatments for acne cause redness, itching and irritation, which make it difficult to continue using them.
The lack of mobile standards and fragmentation inherent in mobile can make it difficult to execute campaigns.
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But all too many countries have underdeveloped property systems and make it difficult to establish new businesses legally.
This kind of anxiety can make it difficult to think clearly, Chansky says.
Dixon thinks that in the long run that will make it difficult to maintain pricing for such generic waters.
And strict historical codes can make it difficult to change a house's exterior.
Bisaillon continues to do business in Montreal, confident that Canada's weak enforcement statutes make it difficult to convict him.
Even if Apple were inclined to spend billions a year for those shows, contracts make it difficult to impossible.
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Rallying markets make it difficult to sit on the sidelines, but investors should keep a close eye on the Fed.
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Yet New Guinea's awkward geography, poor infrastructure and myriad ethnic divisions make it difficult to mount an effective prevention campaign.
P. caucus in the Senate, that threat alone, if carried out again, would make it difficult to peel off Republican votes.
While that is an encouraging sign, output is growing at rates that make it difficult to sustain the current unemployment rate.
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Is it going to put us in a deficit and make it difficult to pay for our real needs versus wants?
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Policymakers in the euro area find themselves constrained by the fiscal deficits that make it difficult to inject stimulus into their economies.
From my perspective, this is a simple problem that has very complicated politics and emotion that make it difficult to make progress.
These uncertainties make it difficult to decide how much insurance to buy.
Tight correlations across industries, nations, and stock-size categories make it difficult to balance one kind of equity against another for a smoother ride.
Under bankruptcy protection the courts can relieve a company of its debts and rescind contracts that make it difficult to continue in business.
Having grown up in Baghdad, both rowers know the frequent disruptions to their training will make it difficult to do well in London.
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