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Having crashed out at Wimbledon in June the Scot did not find her best form until the US Open in August, when she won her first ever main draw match at Flushing Meadows by beating, ironically, Martic.
BBC: Wimbledon slump rocked Elena Baltacha
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Vandeweghe defeated Italy's Tathiana Garbin 6-4 6-4 for her first victory in a WTA Tour main-draw match.
CNN: Sharapova on song as L.A. seeds tumble
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Last year, he became the first U.S. junior champion in decades to win a match in the main draw.
FORBES: Andy Roddick Announces Retirement at U.S. Open, but Who's America's Next Tennis Champion?
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Azarenka's withdrawal allowed 19-year-old Lauren Davis into the main draw, and she took her chance -- saving three match points against Madison Keys before beating her fellow American 6-1 5-7 7-6 (9-7) in the second-round match.
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"It'll be my first time in the main draw of these events and I'll just be taking it one match at a time when I'm out there, " she said.
BBC: Keothavong enters world's top 50
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In the only other first-round match on the opening day, Spain's Conchita Martinez ousted the only German player in the main draw, wild card Anna-Lena Groenefeld, 7-6 6-2.
BBC: SPORT | Tennis | Clijsters: Serena still the best