Cordaptive combines niacin, an already approved heart medicine, with a new drug that alleviates niacin's main side effect, hot-flash-like flushing.

FORBES: Magazine Article

But overall the main effect of this is to - is to energize the Tea Party groups and the Republican base.

NPR: With White House Bogged Down By Scandal, GOP Looks For Boost

Earlier this week, the Council of Mortgage Lenders said the main effect of FLS so far was to make fixed-rate mortgage deals, which account for about two-thirds of all new mortgage borrowing, a bit cheaper than before.

BBC: Bank of England

In a 2002 New England Journal of Medicine article, metformin was shown to reduce the progression of pre-diabetes to diabetes by 30%, with the main side effect being gastrointestinal symptoms.

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"A 5mm (0.2 inches) particle striking a large solar array is likely to have a very little long-lasting effect, but such an object hitting the main body of a satellite could cause a vital component to fail, " he said.

CNN: Space harpoon plan to nail orbital garbage

The main effect of previous debates has been on perceptions of the less-experienced candidate.

ECONOMIST: On to Winston-Salem

David Autor, of the Massachusetts Institute of Technology (MIT), points out that the main effect of automation in the computer era is not that it destroys blue-collar jobs but that it destroys any job that can be reduced to a routine.

ECONOMIST: A university degree no longer confers financial security

Mr Coogan warned that the bank's efforts had yet to have much effect on the London Inter-Bank Offered Rate (Libor), the main interest rate governing the cost of lending between banks.

BBC: Mortgage lending hits 33-year low