The inflammation theory helps explain why even someone with low cholesterol can have a heart attack, and why so many patients with no previous symptoms can suddenly be struck down.
But a more recent study of 12, 000 American men and women found that high Lp-PLA2 levels were an independent heart-disease risk factor mainly in those patients with relatively low cholesterol levels.
John Kastelein, the University of Amsterdam researcher who conducted the studies with Isis, says that if physicians eventually get to add 301012 to their arsenal, it will be possible to get "virtually anyone" to the aggressively low cholesterol goals that have been set by government-organized committees.
Shark Bar -- Stylish African-American temple of updated soul food is the place for those weary of low-fat, low-cholesterol offerings.
Fish is low in cholesterol (50 to 90 milligrams per 100 grams).
There is no evidence that really low LDL cholesterol levels are harmful.
Nobody made buffalo-hide shoes, and there was a ready supply of raw material: Ranchers slaughtered about 14, 000 bison each year to meet the growing demand for low-cholesterol meat.
These studies had led to new cholesterol guidelines in the U.S. that suggested lowering low-density lipoprotein (LDL), or bad cholesterol, to extemely low levels.
Zetia was, in fact, a breakthrough for patients who can't get their cholesterol low enough with other drugs.
Until heart researchers figure it all out, patients with low good-cholesterol levels can try to get healthy without Big Pharma's help, doctors say.
"Bad" cholesterol - low density lipoproteins (LDL) - contribute to furring of the arteries.
Following the DASH diet means eating foods that are low in fat, cholesterol and salt.
"The system is set up so that the HDL high density lipoproteins, or artery-cleaning or 'good' cholesterol, cleans out the LDL low density lipoproteins, or 'bad' cholesterol, " she explains.
Statins help lower low-density lipoprotein cholesterol, or "bad" cholesterol.
He was also starting to figure out, along with a number of other emu ranchers in the mid-1990s, that meat of the flightless animal, despite being low in fat and cholesterol, doesn't fly with diners.
KYNAMRO, given as a 200 mg weekly subcutaneous injection, has been approved as an adjunct to lipid-lowering medications and diet to reduce low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (Apo B), total cholesterol (TC), and non-high density lipoprotein-cholesterol (non HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH).
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
"Bad" cholesterol - or low density lipoprotein - can block arteries and cause heart disease.
Even former President Bill Clinton was said to have stopped taking his cholesterol medicine once his cholesterol levels got low.
The addition of Kynamro helps to reduce low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B, total cholesterol, and non-high density lipoprotein-cholesterol (non HDL-C).
FORBES: FDA Approves Mipomersen For Homozygous Familial Hypercholesterolemia
It may be helpful for avoiding high doses of statins in patients who do not meet cholesterol goals on low dose statin therapy alone.
The claim states that a diet rich in whole-grain foods and low in saturated fat and cholesterol may help reduce the risk of heart disease.
But when Zetia was combined with a statin like Lipitor or Zocor, it lowered bad cholesterol, or low-density lipoprotein (LDL), more than anything else out there.
But even the ones marketed as "low fat" or "cholesterol lowering" are loaded with sugar which the latest evidence suggests is the most potent driver of obesity.
In an effort to tease out the effect of Zetia, researchers looked at a subgroup of patients who were supposed to lower their cholesterol to very low levels.
In Ridker's study, patients with high bad cholesterol, or low-density lipoprotein and high CRP had heart attacks, strokes or heart procedures 9.9% of the time compared with 4.9% of the time for patients where both risks were low.
Doctors use the scoring systems to single out patients who could benefit from counseling about lifestyle changes, such as losing weight and quitting smoking, or from preventive interventions such as low-dose aspirin and cholesterol drugs, says Yul Ejnes, the chairman of the American College of Physicians board of regents.
Coronary artery disease begins when excess cholesterol particles, called low-density lipoprotein particles, become lodged in the artery wall over time and get chemically damaged, or oxidized (close-up diagram).
He is, however, worried that people with high cholesterol would take relatively low doses when they should be taking higher ones to really reduce their risk of heart attacks.
For patients at the highest risk of heart attack, the new guidelines suggest that "bad cholesterol, " or low-density lipoprotein (LDL), be reduced to 70 mg per deciliter--although the new guideline is optional.
Both work by inhibiting an obscure molecule called the cholesterol ester transfer protein (CETP) that works indirectly to prevent HDL from being used to create low-density lipoprotein (LDL), the bad cholesterol.
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