The custodians are all regulated by the SEC and FINRA, audited by a nationally recognized accounting firm, and each account is protected for loss of securities by a combination of SIPC insurance and commercial excess Securities Investor Protection Corporation (SIPC).
Staying well hydrated is the most effective way to prevent a hangover- drinking plenty of water throughout the day, and avoiding excess amounts of caffeine, especially high octane energy drinks loaded with plenty of caffeine which lead to loss of water from your body.