This is surprising because Bydureon is a long-acting version of an already approved drug, Byetta.
Roche is developing a similar, long-acting GLP-1 drug, and it might face similar problems.
Partners Eli Lilly and Alkermes, whose drug delivery technology makes Bydureon long-acting, could also hurt.
And many patients will still have to take at least one injection of long-acting insulin.
The short meets sugar challenge from lunch and the long-acting meets the sugar from dinner.
Now the company is emerging from the patent cliff with the long-acting-insulin, Lantus, leading the way.
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It has a special ultra-long-acting mechanism that also aimed to make it more abuse resistant than standard stimulants.
At breakfast, many diabetics take an injection of mixed short- and long-acting insulin.
For Type 1 diabetics, the once-a-day Lantus or another long-acting insulin, Levemir from Novo Nordisk, can provide important benefits, Buse says.
The cartridge system is not very useful for the patients who have to mix immediate and long-acting insulins at a dose.
That left Aventis as a pure-play drugmaker whose products include Allegra, a blockbuster antihistamine, and Lantus, a long-acting form of insulin.
The Risk Evaluation and Mitigation Strategy (REMS) targets extended-release (ER) and long-acting (LA) opioid drugs, including prescription medications containing oxycodone hydrochloride.
The most commonly used medications are the stimulants, like Ritalin or Adderall, or their long-acting equivalents, like Concerta, Ritalin LA, or Adderall XR.
Nationally, asthma deaths have eased recently, even as use of long-acting beta agonists has risen, Rickard notes, inconsistent with an epidemic of drug-induced deaths.
The FDA comes up with another safety question that must be resolved, the same way it got worried about the long-acting diabetes drug Bydureon.
Reclast is long-acting--women can't forget to take their pills.
There are a number short-acting insulins and long-acting insulins.
Apparently the FDA is concerned that the higher drug concentrations produced by the long-acting version will push some patients into the danger zone, especially patients with kidney problems, a common complication of diabetes.
Babatunde Osotimehin: One good example of that is Ethiopia, where about 38, 000 health extension workers are leading the effort to bring long-acting modern family planning methods closer to communities, especially to isolated and rural ones.
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Also consider long-acting decongestant sprays or tablets, which help keep blocked nasal passages open when cabin pressure changes during take-off and landing. (Decongestant can be overly drying in airplane cabin air so consider saline solution, too).
Aventis' Lantus, the first real, once-a-day, long-acting version of the hormone, will in all likelihood be the first choice of many doctors for treating patients, because it avoids the multiple injections and unsteady response involved in earlier versions of the drug.
Treatment often includes inhaled corticosteroids, to reduce inflammation, and long- and short-acting beta agonists like albuterol, to relax airway muscles.
They include the device, entertaining and annoying in equal measure, of periodic appearances by Michael Gambon as Julia's long-dead acting teacher, who keeps reminding her that the only reality is the theater, and anything else is fantasy.
Is Nintendo really making a wise and logical move that works out in the long-term, or simply acting out of the same out-of-touch myopia that could doom them?
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Dr Eberhard says this shows whatever biochemical is introduced into the spiders' bodies is fast-acting and long-lasting.
The minute-long spot showed people acting like cars on the road, walking on the street as a simple piano piece played.
However they are not acting in the long-term best interest of either of their countries.
The Treasury insists it is acting in the long-term interests of consumers.
When you ask that same individual to begin by acting in alignment with that long-term thinking idea-how many would ready, willing and able to act?
Dr Cottrell does not believe that thiopental has any long-term adverse affects, though Vincent Iacopino, acting director of research for Physicians for Human Rights, an American charity, cautions that it can be addictive.
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