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Uruguay coach Javier Aguirre brought on the highly rated Lodeiro in place of Gonzalez shortly after the restart, and Domenech replaced Gourcuff with Malouda.
BBC: Uruguay 0-0 France
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Uruguay talisman Luis Suarez dragged his side back into the tie, with a key role in both Gaston Ramirez's equalizer and Nicola Lodeiro's winner.
CNN: Spain suffer shock defeat to Japan
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Lodeiro's only mark on the game was arguably made on the ankle of Bakari Sagna as the Uruguayan picked up his second booking with 10 minutes to go.
BBC: Uruguay 0-0 France
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In a game of few chances, Uruguay came closest to scoring through a Diego Forlan shot that was saved in the opening half, while they finished the contest with 10 men after substitute Nicolas Lodeiro picked up two bookings.
BBC: Uruguay 0-0 France