And the poor transport links will always make businesses, let alone multinationals, think twice about locating in the area.
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Firms locating in London can tap into a huge specialist financial workforce drawn from both domestic and foreign sources.
Another big attraction of locating in San Francisco is much lower rents.
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Republican governors in states such as Ohio, Nebraska and Louisiana argue income taxes impede economic growth and discourage businesses from locating in their states.
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By locating in these startup capitals, a new entrepreneur becomes part of a vast network, which is helpful for raising funds and also for the learning curve.
The benefits to firms and workers of locating in an area with a thick labor market are why innovative sectors tend to concentrate in a few cities worldwide.
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Leanne Wood AM asked Mr Jones how many jobs would be lost and companies put off locating in Milford Haven if the Trident submarine was relocated to the area.
The big reason behind locating in New Orleans with the expansion has been in our ability to find competitive pricing, which allows us to have a unique hook when recruiting.
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Business programs from every federal agency have been thoroughly ramped up, and a new initiative targeting foreign companies thinking about locating in the United States, SelectUSA, was launched in 2011.
The system could help avoid "near miss" incidents and aid in locating aircraft in the event of an emergency.
Did they make a mistake in locating their European bases in Britain?
After locating plants in other countries like China, Intel is opening its most advanced plant right here at home.
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Naturally, locating itself in three different countries creates management challenges for BonitaSoft.
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In the first letter, from Jan. 15, 1983, Chapman says his reason for writing, besides wanting to be Spiro's friend, is to ask for help in locating his copy of "The Catcher in The Rye, " which he was reading at the time of his arrest.
But recent days have seen a range of indicators published that give us some help in locating where the Scottish economy is now positioned in recovering from recession.
Analysing the sea in this way might prove useful, too, in rescuing people whose boats have broken down or in locating the wreckage of aircraft that have crashed in mid-ocean.
The venture-capital industry specializes in locating and assuming the large risks of this sort of investment in return for a share of the rewards when successful.
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The list included companies as diverse as Garmin and John Deere and any company that sells products that utilize global positioning for airline or sea navigation, for planting seeds in a field, for locating lost climbers or hikers in the wilderness and so forth.
Robert Dennis had a lot of trouble locating pay phones in his home of Coral Springs, Florida.
Scientists measure historic carbon dioxide concentrations by, for example, locating trapped bubbles in the ice of ancient glaciers.
But it is not known whether these tests were central to the Americans' success in locating Bin Laden.
Once approved for the maximum loan, Locascio wasted little time in locating and bidding on a property she liked.
Data integration is a problem cited by 67%, and 39% have issues in locating where the data may reside.
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And there are obvious disadvantages in locating at the heart of a metropolis.
While Hason makes a good case for locating his company in Newton, time will tell whether he made the right decision.
Authorities said they are asking the public for help in locating Magnotta, after a "coast-to-coast" warrant was issued for his arrest.
You'll have to watch the show to find out whether Ballard succeeded in locating this relic of the first shot fired at Pearl Harbor.
Last week, Israel's Supreme Court issued a ruling that calls into question the long-standing policy of locating Jewish communities in areas for strategic purposes.
That includes any luck in locating Tsarnaev's laptop computer, which a law enforcement official with knowledge of the investigation had said investigators were looking for.
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