Argentina captain Lisandro Arbizu has not recovered from a head injury sustained against the French.
And Lisandro's penalty gave Lyon a two-goal cushion after Matthieu Chalme was harshly penalised for handball.
It's a surprise that Lisandro has fitted in so quickly, but we knew he had a strong temperament.
Nonetheless, referee Felix Brych pointed to the spot and Lisandro stepped up to send Carrasso the wrong way.
But gradually Lyon moved into the ascendancy, with Lisandro Lopez and Delgado threatening from the edge of the area.
Lisandro Lopez put the hosts ahead after a mistake by Michael Ciani, but Marouane Chamakh headed in a 14th-minute equaliser.
Lisandro's joy was shortlived, as a booking - which also looked harsh - ruled him out of the second leg minutes later.
The dream looked like it had died when Lisandro Lopez converted a penalty to leave Epinal's hopes in tatters with just 28 minutes remaining.
As well as Lisandro, Aly Cissokho was purchased from Porto, Brazilian Michel Bastos came in from Lille, and France forward Bafetimbi Gomis arrived from St Etienne.
In the first minute of the second half Lisandro Lopez gave Argentina a 2-1 lead, with Jesus Datolo adding a third just before the hour mark.
Lisandro's arrival in France's culinary capital was no knee-jerk reaction to the departure of the home-grown Benzema - it was a transfer two years in the making.
Indeed, only three months into his French "sojourn" and a poll of football supporters in France has deemed Lisandro to be a better player than his predecessor Benzema.
Attacking trio Hulk, Lisandro and Cristian Rodriguez caused United's defense big problems last week, suggesting Ferguson will be thankful to have Rio Ferdinand available after a recent groin injury.
Casillas was left helpless for the goal but a woeful clearance from the goalkeeper shortly after fell straight to Lisandro - only for the Argentine to drag his shot wide.
Porto made two substitutions at the start of the second half - Raul Meireles and Lisandro Lopez coming on - but within three minutes of the restart the visitors found themselves two goals behind.
Lyon made two changes at the break and showed far more attacking intent, with Sidney Govou firing wildly over when well placed inside the area and Lisandro Lopez testing Iker Casillas with a fierce, swerving shot from distance.
Porto had clearly decided that attack was the best form of defense, and Lisandro had already seen a viciously swerving shot turned over by Edwin van der Sar when Rodriguez capitalised on two woeful pieces of United play to open the scoring.
Lisandro Lopez missed a golden opportunity to make it 2-1 on the night when he dragged horribly wide after Lyon had three on one on the break, but it did not prevent his side from reaching their fourth Champions League quarter-final, their first since 2006.
The quality of the signings was not questioned - only Lionel Messi, Steven Gerrard and Miroslav Klose were more prolific than Lisandro in last season's Champions League - but Lyon coach Claude Puel has admitted to being surprised at how quickly the new faces have "hit it off".
应用推荐