Re-energised, Jones knocked Griffin out in a single round to claim the WBA light-heavyweight crown.
The Nairn-based light-heavyweight discovered that he was suffering from the disorder almost by chance four years ago.
Lets get things straight I'm a big light-heavyweight and he's a super-middleweight, I think he's seen sense.
Eight months later, Jones challenged Antonio Tarver for his WBC light-heavyweight belt and nicked a contentious majority decision.
That ended the American's unbeaten run and shattered his reputation as the top man in the light-heavyweight division.
Light-heavyweight Jeffries, 23, is tipped to quit the amateur ranks and feels the time is right to turn pro.
The 25-year-old light-heavyweight will be managed by former world champion Naseem Hamed and joins promoter Frank Warren's stable of fighters.
Hobson guided Sheffield's Clinton Woods to the IBF light-heavyweight title and also promoted some of Ricky Hatton's fights in the United Kingdom.
Sheffield boxing promoter Dennis Hobson has also tried to tempt Calzaghe out of retirement with a clash against light-heavyweight fighter Clinton Woods.
The Vanquish looks like a light-heavyweight boxer sewn into his own waistcoat.
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The undefeated Welshman pulled out of their light-heavyweight bout on 20 September at the Garden after injuring his right hand in training in July.
Frenchman Antoine Palatis, who died recently in retirement, achieved the feat of winning domestic light-heavyweight and heavyweight titles despite suffering from Type One diabetes.
In his next outing in October 2008, Cleverly impressed with a breakthrough points victory over hardened veteran Tony Oakey to claim the Commonwealth light-heavyweight title.
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By 1984, he had compiled an amateur record of 145-17 and a place as a light-heavyweight in the Olympic team that went to Los Angeles.
British boxers surpassed their Beijing target with bronze medals for light-heavyweight Tony Jeffries and super-heavyweight David Price, and a superb gold for middleweight James DeGale.
"I respect him but Hopkins is not as good as he thinks he is, " said Calzaghe, who will be making his first appearance as a light-heavyweight.
Antonio Tarver, the now dethroned undisputed light-heavyweight champion, unleashed a low blow on the tussle of the old-timers for The Ring Magazine light-heavyweight belt on Saturday.
Calzaghe, 36, added that he was punching harder than ever ahead of his light-heavyweight debut and he plans to become the first man to stop Hopkins.
The 26-year-old previously held the European super-middleweight title but stepped up a division to claim the fringe WBO intercontinental light-heavyweight title against Sergey Demchenko last August.
"I won the heavyweight title then came back to win the light-heavyweight title, " said Jones, a cockfighting and fishing enthusiast from the small town of Pensacola, Florida.
Jones admitted the fight would be his last as a light-heavyweight and that he was hoping to line up just one more fight - with Mike Tyson.
But the Welshman, who will fight Roy Jones Jr at light-heavyweight on 8 November, warned that the 22-year-old still had a lot to learn in the sport.
The 36-year-old stepped up to the light-heavyweight division to fight Bernard Hopkins in Las Vegas in April where his points victory won Calzaghe the prestigious Ring Magazine title.
Jeffries also won a medal in Beijing, taking light-heavyweight bronze.
"Every fighter wants recognition not just from his own people but from fans all over the world, " said Calzaghe, who will also be fighting at light-heavyweight for the first time.
Maccarinelli was fighting on the same bill as compatriot Nathan Cleverly, who closed in on a world title shot after defending his European light-heavyweight title with a 10th-round stoppage of Karo Murat.
It was a first defeat for Hopkins, the nephew of former middle and light-heavyweight champion Bernard Hopkins, while Holt is now in line for a unification bout next year against WBC champion Timothy Bradley.
Nathan Cleverly, from New Tredegar in Caerphilly county, won the Commonwealth light-heavyweight title in October after a gruelling 12-round fight against Portsmouth's Tony Oakey and retained it on Friday when he beat Kenyan Douglas Otieno.
Also featuring on the card is 2002 Commonwealth Games champion Jamie Arthur, Pontypool welterweight Tony Doherty, Mountain Ash light-heavyweight Nathan King, Abercynon welterweight Taz Jones and Rhondda Valley light-welterweight Barrie Jones, who makes his professional debut.
Cloud is the IBF champion while fellow American Dawson - who does not hold one of the four recognised world light-heavyweight belts - is generally accepted as the leading operator at 175lbs and holds the unofficial Ring Magazine crown.
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