When they hooked up with CD-2, the decoys prevented the real LFA-3 from binding to and activating the T cells.

FORBES: Skin Deep

Biogen scientists crafted decoys by cloning and attaching the binding site of LFA-3 onto the Y-shaped tail of a harmless antibody.

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In the early 1990s, dermatologist Kevin Cooper, then at the University of Michigan, observed that the binding of CD-2 to LFA-3 set off psoriasis' chain reaction.

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They found that T cells went into action when CD-2 bound itself to a counterpart molecule, LFA-3, on the surface of cells that escort antigens to their death.

FORBES: Skin Deep