Decreased oxygenation of leg muscles due to peripheral vascular disease and the pain of diabetic neuropathy can also be mistaken for cramps.

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Diabetic vascular disease is a leading cause of leg amputation.

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Farlow's glassblowing team would then create a heart connected to a vascular system connected to a custom opening in the femoral artery of the leg.

CNN: Hearts of glass: Where medical science meets art