They were just 90 minutes away from a return to the Football League, and things were looking good when Lee Phillips gave them the lead against Morecambe.
U's boss Gary Brabin has plenty of options up front going into the new season with Beesley, Chris Holroyd, Lee Phillips and Danny Crow each competing for a place in the side.
Manager Peter Nicholas was then forced to make two more late changes as defenders Stuart Jones and Lee Phillips withdrew, Phillips with an injury and Jones because he had not been registered with Uefa.
And he said if I buy a Chevrolet, I should have them put on Lee tires because Phillips makes Lee tires.
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Speed's departure from the coaching set-up at the Reebok Stadium leaves Ricky Sbragia and Jimmy Phillips as Lee's first-team coaches.
Williams tore a hamstring in Saturday's 33-12 loss to Australia and joins fellow stars Mike Phillips, Lee Byrne and Adam Jones on the sidelines.
The four were questioned, along with team-mates Lee Byrne and Mike Phillips, by team managers about what they were doing in Cardiff city centre on Sunday.
Injuries mean Jones will lead a squad shorn of fellow Grand Slam heroes Gavin Henson, Martyn Williams, Mike Phillips, Lee Byrne, Dwayne Peel and Huw Bennett.
New contracts will be offered to Paul Barrett, Dan Bennett, Lee Jones, Andy Morrell, Wayne Phillips, Steve Roberts, Kristian Rogers, Steve Thomas and Jim Whitley.
Another try followed from the Ospreys' next attack, Mike Phillips looping around to find Lee Byrne at pace and the full-back handed off Webster to send Tommy Bowe down the touchline.
Williams, Gavin Henson, Ryan Jones, James Hook, Mike Phillips, Alun Wyn Jones, Lee Byrne and new-signing Tommy Bowe are all on course for a call to the prestigious Lions tour to South Africa next summer.
Jamie Heaslip, Mike Phillips, Alun-Wyn Jones, Phil Vickery and Lee Mears are all promoted from the bench.
Phillips, Gavin Henson, Jamie Roberts, Huw Bennett and Jon Thomas return, while Lee Byrne is also in contention.
Tries from Lee Byrne (2), Nikki Walker, Shane Williams (2), Sonny Parker and Mike Phillips secured victory.
Wales, having been led out by 50-cap men Phillips and Ryan Jones, made a nervy start from Ireland's kick-off as Lee Byrne's attempted clearance was charged down by Eoin Reddan.
Five more players - Wales duo Mike Phillips and Alun-Wyn Jones, Ireland flanker Stephen Ferris plus England pair Riki Flutey and Lee Mears - could also taste their first action as a Lion off the bench.
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