Experiments by scientists at Oregon and Portland State Universities leave no doubt that this mutation puts its carriers at a disadvantage.
Repeatedly telling them that he was there to listen with an open mind, other statements leave no doubt that this was anything but the true case.
But Obama has placed such a heavy fingerprint on these policies that success will bring him credit, but setbacks will leave no doubt where the responsibility lies.
Articles and speeches drafted in his own hand leave no doubt that Reagan was exceptionally well read and had an excellent grasp of both history and current issues, including highly technical matters and complex statistics.
Mrs May claimed that the motion would leave judges in no doubt it was in the public interest that foreign criminals should be deported.
The XDJ-Aero does nothing to undermine that rep -- the metal top finish, solid response of the buttons and luxurious-feeling faders and caps leave you with no doubt that this is a solid bit of kit that should easily withstand the knocks and bumps that come with mobile gigging, or just regular enthusiastic use.
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Choosing which comets to put into some grand synthesis, and which to leave out, will no doubt exercise astronomical minds over the next few months.
He swung his cue in a wide arc at head height to leave no-one in doubt about angry he was but that was not the most extreme reaction he was to produce.
"Joining the Millennium Stadium from the chief position at South Wales Police, Gerry brought a unique insight and experience to the role and he will no doubt leave some big boots to fill, " he said.
And, while the Obamas leave snowy Washington behind, and no doubt have memories of frosty Christmas celebrations in Chicago, the average Christmas temperature here explains Santa's shorts: mid-70s.
And if we can do that again -- if we can continue building that foundation and making those hard decisions on behalf of the next generation -- I have no doubt that we will leave our children the America that we all hope for.
Yes, the current scandal will leave a lasting stain on his reputation, and no doubt it raises questions about his integrity.
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Should he decide to leave his home in Madrid to take in one of the world's greatest fixtures, there is no doubt he would be welcomed back with open arms in the city he once adorned.
"I congratulate Real Madrid for their victory and also for their league title which I have no doubt they have clinched tonight, " Guardiola told reporters, as he defended his decision to leave Cesc Fabregas and Gerard Pique on the bench.
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