The Cubs extended their lead to 3-1 in the sixth on Ryan Sweeney's leadoff homer.
Louis rookie Shelby Miller retired the final 27 hitters after allowing a leadoff hit on Friday.
Pirates leadoff man Starling Marte went 0 for 4 and struck out three times.
"I think the whole thing was the leadoff walk in the first inning, " Humber said.
"Obviously disappointing, " said Mets star David Wright, who hit a leadoff triple in the big fourth.
Hafner made it 3-1 with a leadoff longball to left in the third, his fifth.
Cervelli greeted Clayton Mortensen with a leadoff homer in the seventh that made it 4-1.
He looks over at his now-worried pitching coach, understanding the danger of a leadoff walk.
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One day after Adam Rosales hit a leadoff homer for the A's, Jaso nearly duplicated the feat.
Leadoff witness Thomas Okarma, president of biotechnology company Geron Corporation, urged that current restrictions should be kept.
Reyes was back in the leadoff spot in Toronto's lineup for the first time since March 2.
Davis drew a leadoff walk in the 10th and moved up on a sacrifice bunt by Juan Lagares.
One day after Adam Rosales hit a leadoff homer for the A's, John Jaso nearly duplicated the feat.
Robinson Cano ended AL Cy Young Award winner David Price's night with a leadoff single in the ninth.
Jayson Nix hit a leadoff single, went to second on a wild pitch and advanced on Stewart's sacrifice.
Shin-Soo Choo came over in a trade with Cleveland and addresses Cincinnati's gaping hole at the leadoff spot.
Juan Francisco hit a leadoff homer in the third inning and Freddie Freeman connected to start the fourth.
Sweeney tried to stretch a leadoff double into a triple in the fourth but was thrown out at third.
After Obama's Tuesday speech, Hannity's leadoff guest was Karl Rove, the former Bush lieutenant who favors the Senate compromise.
Steve Pearce hit a leadoff double and scored on a single by Markakis.
Price (0-2) didn't like being lifted after giving up a leadoff single to Robinson Cano in the ninth inning.
Toronto answered in the bottom half when Rajai Davis hit a leadoff triple and scored on Melky Cabrera's grounder.
Suzuki started in center and batted leadoff for the second time this season.
Washington and Cincinnati each traded for a leadoff hitter, and Philadelphia added Michael Young to its already potent lineup.
Travis Hafner had a sixth-inning solo homer, and Ronnier Mustelier won it in the 10th with a leadoff homer.
"That's the reason you have to get the leadoff guy out, " Hughes said.
Lucas Duda hit a leadoff homer and Brandon Hicks delivered a RBI double.
Mariners reliever Yoervis Medina gave up a leadoff single to Chris Nelson, who went to second on a wild pitch.
Louis' Shelby Miller gave up a leadoff single then retired 27 in a row in a 3-0 victory over Colorado.
Mattingly said he thought Skip Schumaker, who started in LF and batted leadoff, might be well-equipped to handle Harvey's fastball.
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