The regulations require any facility that releases at least 100 pounds of lead or lead compounds a year to report its releases to the government.

CNN: Bush to leave Clinton lead standards in place

It is a dramatic change from standards requiring reports only if the facility uses 10, 000 pounds of lead or processes 25, 000 pounds of lead compounds annually.

CNN: Bush to leave Clinton lead standards in place

Ultimately such compounds could lead to promising new painkillers, but to reach that stage GSK's labs first have to test hundreds of thousands of different compounds with the vanilloid receptor, hunting for the ones that bind.

FORBES: Magazine Article

In the last few years, researchers have confirmed that cooking meat too long over a dry, intense heat creates small amounts of at least two kinds of compounds that can lead to cancer.

NPR: Summer Hazards: Sunburn ... and Barbecue?

Thanks to its gene-hunting prowess, HGS appears to have an early lead over several rivals pursuing similar compounds.

FORBES: Beyond Talk

The breath-test technology relies on the idea that the biology of tumours can lead to the production of specific "volatile organic compounds", combinations of chemicals unlikely in a healthy person.

BBC: 'Promising results' for bowel cancer breath-test

While highly promising, it is still far from certain that the leukotriene findings will ever lead to safe and effective heart drugs, as most compounds that enter human trials fail.

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In declaring the emergency, Peru's Environment Ministry said the contamination included high levels of lead, barium and chromium as well as petroleum-related compounds.

NPR: Peru Declares Amazon Oil Contamination Emergency

Combinatorial chemistry elaborates lead drugs (such as the one that led to Lillys antimigraine drug) into entire families of related compounds.

FORBES: A hail of silver bullets