Another commanding performance with the bat on Friday would put the tourists on course to secure the victory that would give them a 2-0 series lead and ensure they retain the Ashes with two Tests remaining.
Bell is favourite to take Pietersen's place in the England side for the third Ashes Test at Edgbaston, with the hosts holding a 1-0 lead over Australia.
Australia recovered from a disappointing Ashes to draw the Twenty20 series against England before taking an unassailable 4-1 lead in the teams' one-day meetings with a 51-run win in Brisbane on Sunday.