From all of this, Healy ascertains that any drug approved since 1990 should be considered a possible candidate for late side-effects.

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For some of them this also entailed strange and disturbing side effects: sleepwalking, late-night food binges, even driving in the wee hours while asleep.

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Jonathan Sackner-Bernstein, of the clinical research outfit CliniLabs, says that data on Merck's drug rolofylline "look pretty impressive, " although he does worry about seizures or other side effects cropping up in late-stage trials.

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Most economists in Japan expect the effects of the measures to fizzle out by late summer.

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These medicines, approved starting in the late 1980s, were thought to have less-dangerous side effects than early antidepressants.

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By the time the revenue impact is apparent, it is too late to compete with a consumer product with traction and network effects.

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"The good news is that people who stay up late in front of the television and computer may be able to undo some of the harmful effects just by going back to a regular light-dark cycle and minimizing their exposure to artificial light at night, " Bedrosian says.

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In late 2011, academics at the University of Kent began carrying out a 12-month study into the effects of lap dancing clubs on communities.

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But deadly side effects--a swelling of the nose and throat that can cause suffocation--turned up in late-stage clinical trials.

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