The gene produces a protein that already has reversed diabetes in some lab animals.
That revelation has been confirmed in mice, fruit flies, dogs and other lab animals.
Floyd discovered a compound that seemed to limit the damage from ischemic strokes in lab animals.
It licensed its first DPP-4 inhibitor in 2000, but the drug caused toxicity in lab animals.
Merck is using RNAi technology to switch off genes in lab animals it is using in drug discovery.
Zabara built evidence to support his new theory, working first with lab animals and then inducing seizures in dogs.
His lab showed this protein to be the receptor for VEGF, and that blocking the receptor stunted the growth of tumors in lab animals.
In the mid-1990s researchers found that when they deleted genes responsible for attracting macrophages to the arteries, atherosclerosis all but disappeared--in lab animals, at least.
But if a drug has already been through enough tests in cell cultures and lab animals to justify starting clinical trials, the odds of success have risen to one in nine.
"In order to get cancer in lab animals you have to feed fairly high levels of the drug over a long term, " said Dr. David Acheson, the FDA's assistant commissioner for food protection.
Phthalates have been shown to affect the development of the male reproductive system in lab animals, and a few small studies suggest they may be linked to subtle effects in the reproductive organs of infant boys.
They combined conventional PET imaging, which requires a radioactive tracer to highlight the brain's metabolic activity, with other recent advances in the genetic engineering of brain cells that allows them to target specific brain circuits in lab animals.
WSJ: Brain Science: Mysterious Neural Circuitry Becomes Viewable
There are some studies that suggest harm in laboratory animals, but larger subsequent studies have failed to confirm any of these earlier findings of harm in lab animals, and there are no studies showing any harm in humans under normal consumer use.
And that's not accounting for the time that he and his lab members devoted to breeding the animals.
In Switzerland, Markram has put together a large lab dedicated to studying neurocortical columns in animals.
But in September, two independent groups reported that the same strain of mice, bred from animals furnished by the Brose lab, do not show any social deficits.
Whereas every dog lab now tests the cognition of its animals while their human owners are blindfolded or asked to face away, young children are still presented with cognitive tasks while sitting on their mothers' laps.
According to EU data, about 12 million animals are used in EU countries' lab experiments each year.
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