Something that was a relatively small knock to the financial system led to a global crisis.
Not much, if Webvan fails to move quickly, says Shaheen, because the competition is bound to knock off his delivery system.
The Bank of England warned of these dangers in April, pointing out that signs of vulnerability in one part of the financial system can quickly have knock-on effects in other parts.
There will be a knock-on further down the education system as primary level has to be toughened to meet the demands of secondary to in turn meet the demands of A-levels and so on.
Cushioned by the remarkable achievements of modern medicine, we often fail to appreciate how fragile our healthcare system can be, and the knock-on threat these risks in conjunction could pose to connected social and economic systems.
The US researchers, reported Science magazine, used genetic modification techniques to knock out a mouse gene which is responsible for keeping the immune system in check so that it does not launch attacks on itself.
It is feared any potential benefits from the extra boost of 80bhp for up to six seconds each lap will initially be negated by the system's weight (on average 35kg) and its knock-on effect on balance, weight distribution and reliability, not to mention the cost and anxiety over its safety.
Innovations could take a system that requires sixty-three clinicians for a knee replacement and knock the number down by half or more.
Because of the machinations of the ranking system, which is calculated over a two-year period, he would knock Woods off the top spot on 31 October, provided the American sticks to his plan not to play until 4 November himself.
Consultants have told the BBC there are also concerns over staffing the emergency department, covering holiday and sick leave, and the fact that the rest of the hospital system does not follow a seven-day working pattern shift, which has a knock on effect especially at the weekends.
Merely having and letting employees know there is such a reporting system, even if it's used primarily for discrimination and harassment issues, enables a company to knock off up to three points on the ten-point "culpability score" the feds use to determine the severity of the sentence.
应用推荐