Loew replaced Adler, Jones and Klose with Tim Wiese, Marko Marin and Helmes respectively.
Gomez was the Euro's leading scorer, whereas Klose had not scored in his previous six games.
He boosts their contingent of Germany internationals including Klose, Lukas Podolski, Bastian Schweinsteiger, Jan Schlaudraff and Marcell Jansen.
Gareth Bale's hesitancy then cost Wales after the break as captain Klose headed in from Roberto Hilbert's cross.
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Miroslav Klose put the visitors ahead with just five minutes on the clock after Jason Koumas had lost possession.
Borowski will join up with former Bremen team-mate Miroslav Klose who left Werder to join the Bavarian club last summer.
Klose could have scored twice more in the final stages, as Wales' only shot on target came from Sam Ricketts.
And their task became even harder when Klose pounced in the opening stages to put the run-away Group D leaders ahead.
Podolski, who was born in Poland, and Miroslav Klose, who is half-Polish.
The dominant James Collins twice had to clear yards from his own goalline, and then home captain Miroslav Klose sent a header wide.
Ovrebro then missed what appeared to be a dangerous two-footed lunge from Klose on Felipe, though the worst error was still to come.
The same direct approach brought the opening goal after 20 minutes when a long punt downfield from Manuel Neuer sent Klose racing clear.
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His pass was perfectly weighted into Klose's path and the captain's first-time strike with the outside of his right foot found the bottom corner.
The excellent Schweinsteiger then shaved the crossbar with a beautiful curling effort, but the game was over as a contest moments later when Klose struck again.
That trio, which had started every game until that point, was replaced by veteran striker Miroslav Klose and attacking midfielders Marco Reus and Andreas Schurrle.
Fiorentina levelled when Per Kroldrup swept home but Massimo Gobbi was sent off for an alleged elbow on Robben before Klose won it at the death.
Germany striker Klose failed to impress in his first start this season, and was replaced by Croatia's Ivica Olic -- who soon tested Bremen keeper Tim Wiese.
Bale was the culprit this time as he was robbed on the right flank by Roberto Hilbert, and his perfect chipped cross was headed in by Klose.
Miroslav Klose has done great for Germany but only know is clicking with a club side, and that isnt a top side in the UEFA CL, it is LAzio.
Shaun Wright-Phillips became the first player to be yellow-carded after 29 minutes for a challenge on Jermaine Jones, but striker Miroslav Klose headed Trochowski's resulting free-kick over the bar.
Germany struck again soon after when man of the match Schweinsteiger floated in a free-kick and Ronaldo remained flat-footed while Klose sped by to force the ball beyond Ricardo.
Miroslav Klose's strike gave Germany a 1-0 win over Russia and stretched their lead at the top of Group Four to four points with one round of matches left.
Schweinsteiger, who hit two goals in Germany's 2006 World Cup third-placed play-off success over the Portuguese, struck after 22 minutes -- and Miroslav Klose added a second four minutes later.
Schwarzer did his best to keep the score down, saving twice from Klose, and once apiece from Sami Khedira and Podolski as Germany tore through the Australia defences time and again.
With time running out Robben's drive forced a good save from Sebastien Frey and when Olic headed the rebound on to Klose to nod home he was at least two yards offside.
Loew took the opportunity to rest the likes of Klose, Ozil and Podolski thereafter and, as a result, the Germans were unable to maintain their fluidity in attack in the closing stages.
In the 68th minute, Klose out-jumped Greek goalie Michail Sifakis and headed the ball in for a two-goal lead, and six minutes later Reus volleyed a rebound off Sifakis from eight yards out.
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Klose silenced the 80, 000-strong Russian home crowd when he stabbed the ball home from six metres after a one-two with Lukas Podolski to score his 50th international goal and set Germany on course for victory in Moscow.
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