In the works: tests for kidney injury and sepsis, and a heart attack diagnostic test.
Acute kidney injury (also known as kidney failure) is a major public health concern.
FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs
Patients without pre-existing disease on high potency statins were 34% more likely to be hospitalized with acute kidney injury than patients on other statin regimens.
FORBES: High Potency Statins Linked To Increased Risk For Acute Kidney Injury
But a second pass of the data presented at the meeting of the American Heart Association last November revealed a more specific problem: kidney injury.
Within 120 days of starting treatment there were 4691 hospitalizations for acute kidney injury in patients without pre-existing kidney disease and 1896 hospitalizations in patients with pre-existing disease.
FORBES: High Potency Statins Linked To Increased Risk For Acute Kidney Injury
Patients were tracked for nearly six years, during which time 2, 215 were diagnosed with acute kidney injury that prompted admission to hospital or dialysis (7 in 10, 000 person years).
FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs
The results show that patients taking a double therapy combination of either a diuretic or an ACE inhibitors or ARB with an NSAID were at no increased risk of kidney injury.
FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs
The authors estimated that 1, 700 patients without pre-existing kidney disease would need to be treated with a high potency statin instead of a low potency statin to cause one additional acute kidney injury requiring hospitalization.
FORBES: High Potency Statins Linked To Increased Risk For Acute Kidney Injury
However, a triple therapy combination of a diuretic with an ACE inhibitor or ARB and an NSAID was associated with a 31% higher rate of kidney injury, particularly elevated in the first 30 days of treatment during which it was 82% higher.
FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs
But Ireland coach Declan Kidney has even greater injury concerns, as first-choice full-back Kearney has already been ruled out of Ireland's early games.
The group said that orlistat, sold in prescription form as Xenical and over-the-counter as Alli, causes serious side effects such as liver injury and kidney failure.
Although one patient did die from kidney problems in this study, Nissen says that a biopsy indicated that an injury and pain drugs, not Crestor, were at fault.
应用推荐