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On came Stephen Jones and Dwayne Peel, the Llanelli Scarlets half-back partnership.
BBC: Fear drives Wales team forward
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The Barbarians squad for the upcoming fixture includes Nick Evans and Joe Rokocoko of New Zealand, Dimitri Yachvili and Imanol Harinordoquy of France, James Hook, Duncan Jones and Dwayne Peel of Wales, Sergio Parisse and Mario Castrogiovanni of Italy, Francois Louw of South Africa, and Kahn Fotuali'i of Samoa.
WSJ: Barbarians Shape Up For Lions Rugby in Hong Kong
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Jones and half-back partner Dwayne Peel start against the Azzurri after impressing off the bench in the 30-15 win over Scotland, with Hook and Mike Phillips taking their places among the replacements.
BBC: Jones praise for Wales rival Hook
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Gareth Thomas, Dwayne Peel, Brent Cockbain and Ryan Jones are out injured.
BBC: [an error occurred while processing this directive]
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"I am really pleased that Dwayne has committed to a new deal, " Sale's director of rugby Kingsley Jones.
BBC: Wales scrum-half Dwayne Peel signs new Sale contract