In early-stage testing quinolones had caused liver and joint damage in young rats and dogs.

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If, however, Howard and Beth marry on December 31st, 2013 and elect to file a joint return, the damage is significant.

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At most a couple of thousand patients worldwide have the inherited disorder, which causes recurring fevers, rashes, joint pain and kidney damage.

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There was also the prospect of long-term damage to the joint, plus a hip replacement, that would have affected his day-to-day life outside cricket.

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The bones were put in place to fuse the joint by inserting a plate and 23 screws to repair damage so severe that most horses would not be able to survive it.

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If left untreated, however, teeth grinding can sometimes damage the teeth or cause headaches and TMJ (temporomandibular joint) pain.

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Huddersfield limited the damage until half-time, but it was Saints who started the brighter at the restart, joint skipper Wellens celebrating his 400th appearance for the club by crossing for his 10th try of the season.

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