John Shepherd, a professor of obstetrics and gynaecology at St Bartholomew's, told the Sunday Telegraph the success of Britain's cervical cancer screening programme meant that the disease was being caught in its early stage in many more patients.

BBC: Fresh hope for cancer patients

This dynamic largely played out between John Locke and Jack Shepherd.

FORBES: Is the X-Files Fantasy or Science-Fiction?

In 2005, Thompson helped shepherd Chief Justice John Roberts through the Senate confirmation process and, most recently, he raised money for the defense of I.

CNN: Doctor: Fred Thompson's lymphoma in remission

Stars Shia LaBeouf (Indiana Jones and the Kingdom of the Crystal Skull), Josh Duhamel (Life As We Know It), Tyrese Gibson (Four Brothers) and John Turturro (The Good Shepherd) have returned along with a host of new stars including Patrick Dempsey ("Grey's Anatomy"), Frances McDormand (Fargo) and John Malkovich (Beowulf).

ENGADGET: Transformers: Dark of the Moon Blu-ray due September 30th, 3D version later