Australia had earlier been restricted to 169-7 with Jerome Taylor taking two wickets in the opening over.
The 328-7 was their sixth highest one-day total with Jerome Taylor the pick of the tourists' bowlers with 3-59.
Dwayne Bravo, Jerome Taylor and Australia-born Brendan Nash return to the squad, but Fidel Edwards misses out due to a knee injury.
Denesh Ramdin and Jerome Taylor failed to contribute much and it was left to Fidel Edwards to keep Gayle company until stumps.
Pakistan started shakily, and had just 24 on the board after an hour when Mohammad Hafeez played on to Jerome Taylor for 18.
After an erratic start from Jerome Taylor, Vasbert Drakes came on first-change to dismiss Marvan Atapattu for 15, fishing outside off-stump for Gayle to collect.
Having embarrassed Jerome Taylor with a series of outswingers which the batsman missed, he decided enough was enough and uprooted his off stump with an inswinger.
Just one run was on the board, courtesy of a wide, when Jerome Taylor teased Shane Watson into driving a full-pitched delivery straight to Sarwan at mid-off.
Jerome Taylor is set to join the tour early next week and will be available for the four-day match against England Lions at Derby starting on 30 April.
Yusuf started the assault as he launched Bravo into the evening sky and Yuvraj needed no second invitation, effortlessly clipping Jerome Taylor over mid-wicket for an outrageous six.
West Indies went into the game without pace bowler Jerome Taylor because of injury, and suffered a second blow when batsman Shivnarine Chanderpaul suffered a groin problem while fielding.
The fast bowling remains in the hands of Fidel Edwards, Jerome Taylor and Daren Powell, with rookie Lionel Baker, who made his debut in New Zealand, completing the quartet.
The West Indies bowlers impressed early on, with Jerome Taylor having Ricky Ponting snapped up by skipper Chris Gayle at short mid-wicket after the two openers had fallen cheaply.
Opener Shivnarine Chanderpaul, all-rounder Dwayne Smith and Bradshaw were included in the new line-up, replacing the injured Dwayne Bravo, who has a sore left shoulder, Runako Morton and Jerome Taylor.
This was just his second fifty in 38 innings, but it was typically Prior - busy and punchy - until he aimed a big swipe at Jerome Taylor and lost his stumps.
The final session opened with a couple of meaty drives from Jerome Taylor before he tried to heave Swann across the line and was lbw, then Sulieman Benn was promptly bowled by the off-spinner.
Prince played a watchful and patient innings that probably deserved to reach three figures but he tried to take a second run to the arm of Jerome Taylor at third man and was comfortably run out.
The worst dismissal was the run out of Jerome Taylor who played a stroke gently off the back foot to extra cover and set off for a run, only to be sent back by his partner.
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